No, it's very unlikely. The BHB-ester inside H.V.M.N. Ketone Ester has undergone extensive safety and research testing in humans and the formulation has been improved and refined over time. As a result, in the studies of H.V.M.N. Ketone Ester (involving hundreds of athletes), there were no GI symptoms reported that negatively affected athletes' ability to exercise.
However, different types of ketone esters may cause adverse effects. An exercise study that used an aceotoacetate ketone ester, found that almost all of the athletes felt sick after taking the ester..
Why might this be different to H.V.M.N. Ketone Ester?
- The ketone ester used was an acetoacetate diester. This is a very different compound to the BHB monoester (BHB-ester) used in H.V.M.N. Ketone Ester.
- This acetoacetate ester had only been tried in humans a few times. There were no other published human studies of the compound. This means that the actual formulation (i.e taste, texture) of the ester had not undergone very much refinement.
- The study gave the acetoacetate ester quite soon before maximal exercise, alongside a can of fizzy cola (reportedly to improve the taste). Taking a fizzy drink before exercise likely increases the chance of adverse effects.
Read H.V.M.N. CEO, Geoff Woo's thoughts on the study of the acetoacetate ester here: https://hvmn.com/blog/in-response-to-nyt
Read the formal scientific response to the study of the acetoacetate ester, co-authored by former H.V.M.N. Research Lead, Dr. Brianna Stubbs here: https://www.frontiersin.org/articles/10.3389/fphys.2018.00279/full